Gut microbiota-derived indole 3-propionic acid protects agai…

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Gut microbiota-derived indole 3-propionic acid protects against radiation toxicity via retaining acyl-CoA-binding protein

Article 2020 EN Gold

BACKGROUND: We have proved fecal microbiota transplantation (FMT) is an efficacious remedy to mitigate acute radiation syndrome (ARS); however, the mechanisms remain incompletely characterized. Here, we aimed to tease apart the gut microbiota-produced metabolites, underpin the therapeutic effects of FMT to radiation injuries, and elucidate the underlying molecular mechanisms. RESULTS: FMT elevated…

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11

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14.22

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11 authors
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1 Huiwen Xiao Chinese Academy of Medical Sci… (CN)
2 Ming Cui Corresponding Chinese Academy of Medical Sci… (CN)
3 Yuan Li Chinese Academy of Medical Sci… (CN)
4 Jiali Dong Chinese Academy of Medical Sci… (CN)
5 Shuqin Zhang Chinese Academy of Medical Sci… (CN)
6 Changchun Zhu Chinese Academy of Medical Sci… (CN)
7 Mian Jiang Chinese Academy of Medical Sci… (CN)
8 Tong Zhu Chinese Academy of Medical Sci… (CN)
9 Bin Wang Chinese Academy of Medical Sci… (CN)
10 Haichao Wang Feinstein Institute for Medica… (US)
11 Saijun Fan Corresponding Chinese Academy of Medical Sci… (CN)

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