Gut Microbiota‐Derived 3‐Hydroxybutyrate Blocks GPR43‐Mediat…
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- DOI 10.1002/advs.202306217
- PMID https://pubmed.ncbi.nlm.nih.gov/38742466
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/11267371
- OpenAlex ID W4396895838
- Type Article
- Language EN
- Published 14 May 2024
- Volume 11 (28)
- Pages e2306217
- Source Advanced Science
- Publisher Wiley
- FWCI 4.74
- Countries 1
- Institutions 7
- Added 15 May 2024
- Updated 31 Oct 2026
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Gut Microbiota‐Derived 3‐Hydroxybutyrate Blocks GPR43‐Mediated IL6 Signaling to Ameliorate Radiation Proctopathy
Article 2024 EN Gold
Radiation proctopathy (RP) is a common complication of radiotherapy for pelvic malignancies with high incidence. RP accompanies by microbial dysbiosis. However, how the gut microbiota affects the disease remains unclear. Here, metabolomics reveals that the fecal and serous concentrations of microbiota-derived 3-hydroxybutyrate (3HB) are significantly reduced in RP mice and radiotherapeutic patient…
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54
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14
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4.74
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
14 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Zhenhuang Ge | Sun Yat-sen University (CN) | |
| 2 | Chun Chen | Sun Yat-sen University (CN) Shanghai Jiao Tong University (CN) +2 | |
| 3 | Junyi Chen | Sun Yat-sen University (CN) | |
| 4 | Jiang Zhou | Sun Yat-sen University (CN) | — |
| 5 | Lingming Chen | Guangdong Medical College (CN) | |
| 6 | Yingqi Wei | Sun Yat-sen University (CN) Sixth Affiliated Hospital of S… (CN) | |
| 7 | Haiyang Chen | Sun Yat-sen University (CN) Sixth Affiliated Hospital of S… (CN) | |
| 8 | Lei He | Guangzhou Medical University C… (CN) Guangzhou Medical University (CN) | |
| 9 | Yi Zou | Sun Yat-sen University (CN) | |
| 10 | Xiaoxuan Long | Sun Yat-sen University (CN) | — |
| 11 | Hongyu Zhan | Sun Yat-sen University (CN) | — |
| 12 | Huaiming Wang Corresponding | Sun Yat-sen University (CN) Sixth Affiliated Hospital of S… (CN) | |
| 13 | Hui Wang Corresponding | Sun Yat-sen University (CN) Sixth Affiliated Hospital of S… (CN) | |
| 14 | Yongjun Lu Corresponding | Sun Yat-sen University (CN) |
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