CDK7 inhibition disrupts androgen signaling and induces metabolic rewiring in prostate cancer cells

Prostate cancer (PC) is the second leading cause of cancer-related deaths among men in the United States. The lethality of advanced castration-resistant prostate cancer (CRPC), which is resistant to conventional androgen deprivation therapy, highlights the urgent need for new therapeutic strategies. In this study, we focused on how cyclin-dependent kinase 7 (CDK7) regulates transcriptional program…