Castration-resistant prostate cancer cells are dependent on …

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DOI 10.1007/s00432-022-04475-3
PMID https://pubmed.ncbi.nlm.nih.gov/36401094
PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/10349716
OpenAlex ID W4309412215
Type Article
Language EN
Published 18 Nov 2022
Volume 149 (8)
Pages 5255–5263
Source Journal of Cancer Research and Clinical …
Publisher Springer Science+Business Media
FWCI 1.77
Countries 3
Institutions 7
Added 27 Nov 2022
Updated 29 Oct 2026

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Castration-resistant prostate cancer cells are dependent on the high activity of CDK7

Article 2022 EN Hybrid

PURPOSE: Prostate cancer (PC) is successfully treated with anti-androgens; however, a significant proportion of patients develop resistance against this therapy. Anti-androgen-resistant disease (castration-resistant prostate cancer; CRPC) is currently incurable. Cyclin-dependent kinase 7 (CDK7) is positioned to positively regulate both cell cycle and transcription, the two features critical for th…

11

Citations

31

References

7

Authors

1.77

FWCI

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UN Sustainable Development Goals

1 SDGs

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7 authors

#	Author	Institutions	ORCID
1	Satu Pallasaho	University of Helsinki (FI)
2	Aishwarya Gondane	University of Helsinki (FI)
3	Anni Kuivalainen	University of Helsinki (FI)	—
4	Samuel Girmay	University of Helsinki (FI)	—
5	Siver Andreas Moestue	Norwegian University of Scienc… (NO) Nord University (NO)
6	Massimo F. Loda	Broad Institute (US) NewYork–Presbyterian Hospital (US) +2
7	Harri M. Itkonen Corresponding	University of Helsinki (FI) NewYork–Presbyterian Hospital (US) +1

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