Modulating Androgen Receptor-Driven Transcription in Prostat…
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- DOI 10.1016/j.chembiol.2020.10.001
- PMID https://pubmed.ncbi.nlm.nih.gov/33086052
- OpenAlex ID W3093612331
- Type Article
- Language EN
- Published 20 Oct 2020
- Volume 28 (2)
- Pages 134–147.e14
- Source Cell chemical biology
- Publisher Elsevier BV
- FWCI 6.62
- Countries 3
- Institutions 11
- Added 29 Oct 2020
- Updated 30 Oct 2026
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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
Article 2020 EN Hybrid
Castration-resistant prostate cancers (CRPCs) lose sensitivity to androgen-deprivation therapies but frequently remain dependent on oncogenic transcription driven by the androgen receptor (AR) and its splice variants. To discover modulators of AR-variant activity, we used a lysate-based small-molecule microarray assay and identified KI-ARv-03 as an AR-variant complex binder that reduces AR-driven…
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6.62
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39 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | André Richters | Broad Institute (US) Koch Institute for Integrative… (US) +1 | — |
| 2 | Shelby K. Doyle | Broad Institute (US) Koch Institute for Integrative… (US) +1 | |
| 3 | David B. Freeman | Cambridge Intellectual Propert… (GB) | |
| 4 | Christina Lai Ling Lee | Cambridge Intellectual Propert… (GB) | |
| 5 | Becky S. Leifer | Broad Institute (US) Koch Institute for Integrative… (US) +1 | |
| 6 | Sajjeev Jagannathan | Baylor College of Medicine (US) | |
| 7 | Florian Kabinger | Broad Institute (US) Koch Institute for Integrative… (US) +1 | |
| 8 | Jošt Vrabič Koren | Baylor College of Medicine (US) | |
| 9 | Nicholas B. Struntz | Broad Institute (US) Koch Institute for Integrative… (US) +1 | — |
| 10 | Julie Urgiles | Koch Institute for Integrative… (US) Massachusetts Institute of Tec… (US) | |
| 11 | Ryan A. Stagg | Boston University (US) Koch Institute for Integrative… (US) +1 | — |
| 12 | Brice H. Curtin | Broad Institute (US) Koch Institute for Integrative… (US) +1 | — |
| 13 | Deep Chatterjee | Goethe University Frankfurt (DE) | |
| 14 | Sebastian Mathea | Goethe University Frankfurt (DE) | |
| 15 | Peter J. Mikochik | Cambridge Intellectual Propert… (GB) | |
| 16 | Tamara D. Hopkins | Cambridge Intellectual Propert… (GB) | |
| 17 | Hua Gao | Cambridge Intellectual Propert… (GB) | |
| 18 | Jonathan R. Branch | — | |
| 19 | Hong Xin | — | |
| 20 | Lori Westover | — | — |
| 21 | Gilles C. Bignan | — | — |
| 22 | Brent A. Rupnow | — | |
| 23 | Kristen L. Karlin | Baylor College of Medicine (US) | — |
| 24 | Calla M. Olson | Baylor College of Medicine (US) | — |
| 25 | Thomas F. Westbrook | Baylor College of Medicine (US) | |
| 26 | Joseph P. Vacca | Cambridge Intellectual Propert… (GB) | |
| 27 | Chris M. Wilfong | Cambridge Intellectual Propert… (GB) | |
| 28 | Benjamin Wesley Trotter | Cambridge Intellectual Propert… (GB) | |
| 29 | Douglas C. Saffran | Cambridge Intellectual Propert… (GB) | — |
| 30 | Norbert Bischofberger | Cambridge Intellectual Propert… (GB) | — |
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