Editorial: Proteostasis disruption in neurodegenerative disorders: mechanisms and treatment strategies

Proteostasis -the dynamic balance of protein synthesis, folding, trafficking, and degradationis essential for cellular homeostasis and organismal health. In neurons, which are long-lived and largely irreplaceable, the maintenance of a functional proteome is particularly critical and vulnerable to age-related decline. Indeed, aging represents the major risk factor for most neurodegenerative disorde…