Walking the tightrope: proteostasis and neurodegenerative di…

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2016
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  • DOI 10.1111/jnc.13575
  • PMID https://pubmed.ncbi.nlm.nih.gov/26872075
  • OpenAlex ID W2272042925
  • Type Review
  • Language EN
  • Published 12 Feb 2016
  • Volume 137 (4)
  • Pages 489–505
  • Source Journal of Neurochemistry
  • Publisher Wiley
  • FWCI 2.71
  • Countries 3
  • Institutions 12
  • Added 24 Jun 2016
  • Updated 27 Oct 2026
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Walking the tightrope: proteostasis and neurodegenerative disease

Review 2016 EN

A characteristic of many neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), is the aggregation of specific proteins into protein inclusions and/or plaques in degenerating brains. While much of the aggregated protein consists of disease specific proteins, such as amyloid-β, α-synuclein, or sup…

234

Citations

165

References

9

Authors

2.71

FWCI

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9 authors
#AuthorInstitutionsORCID
1 Justin J. Yerbury Corresponding University of Wollongong (AU) Illawarra Health and Medical R… (AU)
2 Lezanne Ooi University of Wollongong (AU) Illawarra Health and Medical R… (AU)
3 Andrew G. Dillin Howard Hughes Medical Institut… (US) University of California Syste… (US) +1
4 Darren N. Saunders Garvan Institute of Medical Re… (AU) UNSW Sydney (AU) +1
5 Danny M. Hatters The University of Melbourne (AU)
6 Philip M. Beart The University of Melbourne (AU) Florey Institute of Neuroscien… (AU)
7 Neil R. Cashman University of British Columbia (CA) Vancouver Coastal Health Resea… (CA)
8 Mark R. Wilson University of Wollongong (AU) Illawarra Health and Medical R… (AU)
9 Heath W. Ecroyd Corresponding University of Wollongong (AU) Illawarra Health and Medical R… (AU)
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