Using nanoparticles as artificial antigen-presenting cells to activate human CD4 T cells for immunotherapy 4447

Abstract Description CD4 T cell-based adoptive cell transfer (ACT) therapies have shown clinical success across multiple cancer types. However, finding methods to expand the rare antigen-specific precursor population remains challenging. Here, we developed nanoscale artificial antigen-presenting cells (aAPCs) to expand human antigen-specific CD4 T cells in vitro. These aAPCs are nanoscale beads co…