TET2 has endothelial-specific roles in interferon responses that are dysregulated by hyperglycemia in vitro and in vivo

Dysregulated DNA methylation in the endothelium is associated with the development of cardiovascular disease. Ten-eleven translocation 2 (TET2), a DNA demethylase, plays a regulatory role in endothelial function. Loss of endothelial-expressed TET2 correlates with atherosclerosis progression in vivo and alters vasoactive signaling in vitro. Hyperglycemia acts to downregulate TET2 stability and acti…