Cardiac fibroblasts pyroptosis mediated by NLRP3/Caspase-1/GSDMD-N pyroptotic pathway produces CXCL4 via Wnt/β-Catenin signaling and induces cardiac fibrosis

Abstract Severe myocarditis is often accompanied by cardiac fibrosis, but the underlying mechanism has not been fully elucidated. NOD-like receptor protein 3 (NLRP3) inflammation, closely related to apoptosis pyroptosis, participates in the development of myocarditis. Inhibiting pyroptosis mediated by NLRP3 inflammasome can reduce cardiac fibrosis, although its exact mechanism remains unknown. In…