NLRP3 inflammasome activation triggers gasdermin D–independe…
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- DOI 10.1126/sciimmunol.abj3859
- PMID https://pubmed.ncbi.nlm.nih.gov/34678046
- OpenAlex ID W3205681349
- Type Article
- Language EN
- Published 23 Oct 2021
- Volume 6 (64)
- Pages eabj3859
- Source Science Immunology
- Publisher American Association for the Advanc…
- FWCI 10.85
- Countries 2
- Institutions 8
- Added 10 Oct 2025
- Updated 16 Oct 2026
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NLRP3 inflammasome activation triggers gasdermin D–independent inflammation
Article 2021 EN Green
mice. Thus, NLRP3 inflammasome activation overwhelms the protection afforded by GSDMD deficiency, rewiring signaling cascades through mechanisms that include GSDME to propagate inflammation.
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1 SDGsAuthors & Affiliations
11 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Chun Wang Corresponding | Washington University in St. L… (US) | |
| 2 | Tong Yang Corresponding | Washington University in St. L… (US) Xi'an Honghui Hospital (CN) +1 | |
| 3 | Jianqiu Xiao Corresponding | Washington University in St. L… (US) | |
| 4 | Canxin Xu | Aclaris Therapeutics (United S… (US) | |
| 5 | Yael Alippe | Washington University in St. L… (US) | |
| 6 | Kai Sun | Washington University in St. L… (US) Xi'an Honghui Hospital (CN) +1 | |
| 7 | Thirumala‐Devi Kanneganti | St. Jude Children's Research H… (US) | |
| 8 | Joseph B. Monahan | Aclaris Therapeutics (United S… (US) | |
| 9 | Yousef Abu‐Amer | Washington University in St. L… (US) Shriners Hospitals for Childre… (US) | |
| 10 | Judy Lieberman | Boston Children's Hospital (US) Harvard University (US) | |
| 11 | Gabriel Mbalaviele Corresponding | Washington University in St. L… (US) |
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