The zebrafish NLRP3 inflammasome has functional roles in ASC…
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- DOI 10.1074/jbc.ra119.011751
- PMID https://pubmed.ncbi.nlm.nih.gov/31852739
- OpenAlex ID W2996560206
- Type Article
- Language EN
- Published 18 Dec 2019
- Volume 295 (4)
- Pages 1120–1141
- Source Journal of Biological Chemistry
- Publisher Elsevier BV
- FWCI 2.58
- Countries 1
- Institutions 2
- Added 10 Oct 2025
- Updated 20 Oct 2026
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The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosis
Article 2019 EN Hybrid
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is one of the best-characterized inflammasomes in humans and other mammals. However, knowledge about the NLRP3 inflammasome in nonmammalian species remains limited. Here, we report the molecular and functional identification of an NLRP3 homolog (DrNLRP3) in a zebrafish (Danio rerio) model. We found that DrNLRP3's overall structural arch…
75
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69
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7
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2.58
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1 SDGsAuthors & Affiliations
7 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Jiang-Yuan Li | Zhejiang University (CN) | |
| 2 | Yue-Yi Wang | Zhejiang University (CN) | — |
| 3 | Tong Shao | Zhejiang University (CN) | |
| 4 | Dongdong Fan | Zhejiang University (CN) | |
| 5 | Aifu Lin | Zhejiang University (CN) | |
| 6 | Li‐xin Xiang Corresponding | Zhejiang University (CN) | |
| 7 | Jian-zhong Shao Corresponding | Qingdao National Laboratory fo… (CN) Zhejiang University (CN) |
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