Proteostasis and longevity: when does aging really begin?

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99
Citations
49
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2014
Year
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Work Details
  • DOI 10.12703/p6-07
  • OpenAlex ID W4252872000
  • Type Article
  • Language EN
  • Published 03 Feb 2014
  • Volume 6
  • Source F1000Prime Reports
  • Publisher Faculty of 1000
  • FWCI 4.53
  • Countries 1
  • Institutions 2
  • Added 10 Oct 2025
  • Updated 17 Oct 2026
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Proteostasis and longevity: when does aging really begin?

Article 2014 EN Bronze

Aging is a complex process regulated by multiple cellular pathways, including the proteostasis network.The proteostasis network consists of molecular chaperones, stress-response transcription factors, and protein degradation machines that sense and respond to proteotoxic stress and protein misfolding to ensure cell viability.A loss of proteostasis is associated with aging and age-related disorders…

99

Citations

49

References

2

Authors

4.53

FWCI

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2 authors
#AuthorInstitutionsORCID
1 John P. Labbadia Northwestern University (US) Rice Institute (US)
2 Richard I. Morimoto Corresponding Northwestern University (US) Rice Institute (US)
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