Proteostasis and longevity: when does aging really begin?

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107
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2014
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  • DOI 10.12703/p6-7
  • PMID https://pubmed.ncbi.nlm.nih.gov/24592319
  • OpenAlex ID W2086646706
  • Type Article
  • Language EN
  • Published 03 Feb 2014
  • Volume 6
  • Pages 7
  • Source F1000Prime Reports
  • Publisher Faculty of 1000
  • FWCI 4.83
  • Countries 1
  • Institutions 2
  • Added 10 Oct 2025
  • Updated 17 Oct 2026
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Proteostasis and longevity: when does aging really begin?

Article 2014 EN Green

Aging is a complex process regulated by multiple cellular pathways, including the proteostasis network. The proteostasis network consists of molecular chaperones, stress-response transcription factors, and protein degradation machines that sense and respond to proteotoxic stress and protein misfolding to ensure cell viability. A loss of proteostasis is associated with aging and age-related disorde…

107

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2

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4.83

FWCI

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2 authors
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1 John P. Labbadia Northwestern University (US) Rice Institute (US)
2 Richard I. Morimoto Northwestern University (US) Rice Institute (US)
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