The SH2 and SH3 adapter Nck: a two-gene family and a linker …

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  • DOI 10.14670/hh-15.947
  • PMID https://pubmed.ncbi.nlm.nih.gov/10963137
  • OpenAlex ID W2414579727
  • Type Article
  • Language EN
  • Published 01 Jul 2000
  • Volume 15 (3)
  • Pages 947–55
  • Source PubMed
  • Publisher National Institutes of Health
  • FWCI 1.46
  • Countries 1
  • Institutions 2
  • Added 10 Oct 2025
  • Updated 16 Oct 2026
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The SH2 and SH3 adapter Nck: a two-gene family and a linker between tyrosine kinases and multiple signaling networks.

Article 2000 EN Green

SH2 and SH3 adapter proteins connect cell surface tyrosine kinases to intracellular signaling networks. For instance, the SH3-SH2-SH3 adapter Grb2 links receptor tyrosine kinases to the Ras pathway. Nck, composed of three SH3 domains and one SH2 domain, represents a two-gene (alpha and beta) family in mammals. Nckalpha and Nckbeta are expressed in the same cells and appear to have distinct signali…

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1 Wei Li University of Southern Califor… (US) USC Norris Comprehensive Cance… (US)
2 Hongyun She — —
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