Downregulation in the mRNA expression of nuclear hormone receptor liver-X-receptor alpha (LXR-α) by TNF-α is abolished by the antioxidant kaempferol, but not ascorbic acid, in human hepatocarcinoma HepG2 cells

Background: Liver-X-Receptor alpha (LXR-?) plays an essential role in cholesterol metabolism, bile acids, and lipid synthesis. The proinflammatory cytokine TNF-? has been shown to downregulate the expression of LXR-?.Objectives: We investigated the effects of antioxidants kaempferol and ascorbic acid on LXR-? mRNA expression in TNF-? stimulated HepG2 cells.Methods: After the cells have reached 60%…