NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Mo…
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- DOI 10.4049/jimmunol.1201065
- PMID https://pubmed.ncbi.nlm.nih.gov/22753929
- OpenAlex ID W2113589707
- Type Article
- Language EN
- Published 01 Jul 2012
- Volume 189 (4)
- Pages 2006–2016
- Source The Journal of Immunology
- Publisher American Association of Immunologis…
- FWCI 5.92
- Countries 1
- Institutions 2
- Added 10 Oct 2025
- Updated 20 Oct 2026
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NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice
Article 2012 EN Green
Acute inflammation in response to both exogenous and endogenous danger signals can lead to the assembly of cytoplasmic inflammasomes that stimulate the activation of caspase-1. Subsequently, caspase-1 facilitates the maturation and release of cytokines and also, under some circumstances, the induction of cell death by pyroptosis. Using a mouse line lacking expression of NLRP1, we show that assembl…
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1 SDGsAuthors & Affiliations
10 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Martina Kovářová Corresponding | University of North Carolina a… (US) | |
| 2 | Pamela R. Hesker | University of North Carolina a… (US) | — |
| 3 | Leigh A. Jania | University of North Carolina a… (US) | — |
| 4 | MyTrang Nguyen | University of North Carolina a… (US) | — |
| 5 | John N. Snouwaert | University of North Carolina a… (US) | — |
| 6 | Zhidan Xiang | University of North Carolina a… (US) | — |
| 7 | Stephen E. Lommatzsch | University of North Carolina a… (US) | — |
| 8 | Max Tze-Han Huang | University of North Carolina a… (US) | |
| 9 | Jenny P.‐Y. Ting | University of North Carolina a… (US) UNC Lineberger Comprehensive C… | |
| 10 | Beverly H. Koller | University of North Carolina a… (US) |
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