The Grb2 adaptor
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- DOI 10.1016/0014-5793(95)00578-w
- PMID https://pubmed.ncbi.nlm.nih.gov/7641883
- OpenAlex ID W2082372390
- Type Article
- Language EN
- Published 01 Aug 1995
- Volume 369 (1)
- Pages 47–51
- Source FEBS Letters
- Publisher Wiley
- FWCI 2.25
- Countries 1
- Institutions 2
- Added 24 Jun 2016
- Updated 12 Oct 2026
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The Grb2 adaptor
Article 1995 EN
Grb2 is an 'adaptor' protein made of one SH2 and two SH3 domains. The SH3 domains bind to prolinerich motifs in the C-terminal part of the ras exchange factor Sos. Binding of the Grb2 SH2 domain to phosphotyrosine motifs on receptors, or other adaptor proteins such as Shc, recruits this Grb2/Sos complex at the plasma membrane where Sos stimulates nucleotide exchange on ras, then ras activates raf…
130
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52
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4
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2.25
FWCI
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Authors & Affiliations
4 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Pierre Chardin | Centre National de la Recherch… (FR) Institut de Pharmacologie Molé… (FR) | — |
| 2 | Didier Cussac | Centre National de la Recherch… (FR) Institut de Pharmacologie Molé… (FR) | — |
| 3 | S. Maignan | Centre National de la Recherch… (FR) | — |
| 4 | Arnaud F. Ducruix | Centre National de la Recherch… (FR) | — |
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