Staurosporine induces a neuronal phenotype in SH‐SY5Y human neuroblastoma cells that resembles that induced by the phorbol ester 12‐O‐tetradecanoyl phorbol‐13 acetate TPA)

Treatment of SH-SY5Y human neuroblastoma cells with the protein kinase inhibitor staurosporine, induced both morphological and functional differentiation in these cells. The effects of staurosporine were comparable to those induced by the protein kinase C (PKC) activator, 12-O-tetradecanoyl phorbol 13-acetate (TPA), with respect to induction of neuronal differentiation, i.e. neurite outgrowth, inh…