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SHORT COMMUNICATION

Article 1986 EN

Diglycerides function as analogs of the phorbol ester tumor promoters. We compare here the activity of glycerol 1-myristate 2-acetate (GMA) with the corresponding phorbol 12-myristate 13-acetate (PMA). GMA inhibited phorbol ester binding to reconstituted protein kinase C, stimulated protein kinase C enzymatic activity, and, upon addition to intact 3T3 cells, inhibited [125I]EGF binding. Its potenc…

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1 Nancy A. Sharkey National Institutes of Health (US) National Cancer Institute (US) —
2 Peter M. Blumberg National Institutes of Health (US) National Cancer Institute (US)

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