Activation of protein kinase C attenuates the cyclic GMP res…
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- DOI 10.1016/0014-5793(92)81298-z
- PMID https://pubmed.ncbi.nlm.nih.gov/1324189
- OpenAlex ID W1968992758
- Type Article
- Language EN
- Published 24 Aug 1992
- Volume 308 (3)
- Pages 301–304
- Source FEBS Letters
- Publisher Wiley
- FWCI 0.51
- Countries 2
- Institutions 2
- Added 10 Oct 2025
- Updated 01 Oct 2026
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Activation of protein kinase C attenuates the cyclic GMP responses to C‐type natriuretic peptide in cultured mouse astrocytes
Article 1992 EN Bronze
C-type natriuretic peptide (CNP), a recently discovered natriuretic peptide, has a potent stimulatory effect on cyclic GMP (cGMP) formation in cultured mouse astrocytes. Pretreatment of astrocytes with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), attenuated CNP-induced cGMP responses in a dose-dependent manner, with a half-maximal inhibitory concentration of 6 nM,…
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5 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | V.T.F. Yeung | Chinese University of Hong Kon… (HK) | — |
| 2 | Stanley K. S. Ho | Chinese University of Hong Kon… (HK) | — |
| 3 | Clive Stewart Cockram | Chinese University of Hong Kon… (HK) | — |
| 4 | C.M. Lee | Chinese University of Hong Kon… (HK) | — |
| 5 | M. Gary Nicholls | University of Otago (NZ) | — |
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