Suppression of the first stage of phorbol 12-tetradecanoate …
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- DOI 10.1073/pnas.81.18.5858
- PMID https://pubmed.ncbi.nlm.nih.gov/6435122
- OpenAlex ID W2065627103
- Type Article
- Language EN
- Published 01 Sep 1984
- Volume 81 (18)
- Pages 5858–5862
- Source Proceedings of the National Academy of S…
- Publisher National Academy of Sciences
- FWCI 3.79
- Countries 1
- Institutions 1
- Added 24 Jun 2016
- Updated 27 Oct 2026
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Suppression of the first stage of phorbol 12-tetradecanoate 13-acetate-effected tumor promotion in mouse skin by nontoxic inhibition of DNA synthesis.
Article 1984 EN Green
In order to evaluate the significance of epidermal cell proliferation for the first stage of skin tumor promotion, the effect of hydroxyurea (HU), an inhibitor of DNA synthesis, on tumor formation was studied. Mice initiated with 7,12-dimethylbenz[a]anthracene received a single dose of phorbol 12-myristate 13-acetate (PMA) in stage I of promotion, followed by twice weekly application of the irrita…
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1 SDGsAuthors & Affiliations
5 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Volker Kinzel | German Cancer Research Center (DE) | — |
| 2 | Heinz Loehrke | German Cancer Research Center (DE) | — |
| 3 | Klaus Goerttler | German Cancer Research Center (DE) | — |
| 4 | Gerhard Fürstenberger | German Cancer Research Center (DE) | — |
| 5 | Friedrich Marks | German Cancer Research Center (DE) | — |
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