Tumor Promotion by Phorbol Esters in Skin: Evidence for a Me…

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66
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21
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1983
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  • DOI 10.1126/science.6828884
  • PMID https://pubmed.ncbi.nlm.nih.gov/6828884
  • OpenAlex ID W1996611309
  • Type Article
  • Language EN
  • Published 01 Apr 1983
  • Volume 220 (4592)
  • Pages 89–91
  • Source Science
  • Publisher American Association for the Advanc…
  • FWCI 5.58
  • Countries 1
  • Institutions 1
  • Added 10 Oct 2025
  • Updated 12 Oct 2026
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Tumor Promotion by Phorbol Esters in Skin: Evidence for a Memory Effect

Article 1983 EN

By means of a two-stage promotion protocol in mouse epidermis with 12-O-tetradecanoylphorbol-13-acetate as first-stage promoter and 12-O-retinoylphorbol-13-acetate as second-stage promoter, the effects of the former that are critical and obligatory for tumor promotion were shown to be irreversible in nature for at least 8 weeks. The reversibility of tumor promotion was related to the second stage…

66

Citations

21

References

3

Authors

5.58

FWCI

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1 SDGs
Authors & Affiliations
3 authors
#AuthorInstitutionsORCID
1 Gerhard Fürstenberger German Cancer Research Center (DE) —
2 Bernd L. Sorg German Cancer Research Center (DE)
3 Friedrich Marks German Cancer Research Center (DE) —

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