Regulation of estrogen receptor-alpha gene expression by epi…
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- DOI 10.1677/joe.0.1650371
- PMID https://pubmed.ncbi.nlm.nih.gov/10810301
- OpenAlex ID W1983901656
- Type Article
- Language EN
- Published 01 May 2000
- Volume 165 (2)
- Pages 371–378
- Source Journal of Endocrinology
- Publisher Bioscientifica
- FWCI 2.92
- Countries 2
- Institutions 3
- Added 24 Jun 2016
- Updated 31 Oct 2026
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Regulation of estrogen receptor-alpha gene expression by epidermal growth factor
Article 2000 EN Bronze
The role of epidermal growth factor (EGF) in the regulation of estrogen receptor-alpha (ER-alpha) gene expression in the human breast cancer cell line MCF-7 was investigated. Treatment of cells with 0.4 ng/ml EGF resulted in an approximately 60% decrease in ER-alpha protein concentration by 6 h and the amount of receptor remained suppressed for 24 h. Ligand binding assays demonstrated that the dec…
81
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29
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5
Authors
2.92
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
5 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Adriana Stoica | Georgetown University (US) Georgetown Lombardi Comprehens… (US) | — |
| 2 | Miguel Saceda | Universitat de Miguel Hernánde… (ES) Georgetown University (US) +1 | |
| 3 | VL Doraiswamy | Universitat de Miguel Hernánde… (ES) Georgetown University (US) +1 | — |
| 4 | C Coleman | Universitat de Miguel Hernánde… (ES) Georgetown University (US) +1 | — |
| 5 | MB Martin | Universitat de Miguel Hernánde… (ES) Georgetown University (US) +1 | — |
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