Decrease in estradiol-stimulated progesterone receptor produ…

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1989
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  • PMID https://pubmed.ncbi.nlm.nih.gov/2783381
  • OpenAlex ID W1605466345
  • Type Article
  • Language EN
  • Published 01 Feb 1989
  • Volume 49 (3)
  • Pages 576–80
  • Source PubMed
  • Publisher National Institutes of Health
  • FWCI 2.86
  • Countries 1
  • Institutions 2
  • Added 24 Jun 2016
  • Updated 30 Oct 2026
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Decrease in estradiol-stimulated progesterone receptor production in MCF-7 cells by epidermal growth factor and possible clinical implication for paracrine-regulated breast cancer growth.

Article 1989 EN

These studies have evaluated the modulation by epidermal growth factor (EGF) of estrogen receptor (ER) levels and estradiol-stimulated progesterone receptor (PgR) synthesis. Short-term culture of MCF-7 cells in an "estrogen (phenol red indicator)-free" environment caused a rise in ER concentration that is inhibited by EGF at 10(-8) M and 10(-7) M. Estradiol at 10(-10) M induced a 5-fold increase o…

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1 Ethel M. Cormier University of Wisconsin–Madiso… (US) University of Wisconsin Carbon… (US) —
2 M F Wolf — —
3 Virgil Craig Jordan —
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