nNOS goes nuclear: nNOS‐ and NADPH oxidase‐derived reactive oxygen/nitrogen species promote oxidative nuclear damage in alveolar epithelial cells.

Rationale: Although emerging evidence implicates a role for angiotensin II (Ang II)‐stimulated reactive oxygen and nitrogen species (ROS/RNS) formation in acute lung injury (ALI), details of the mechanism are lacking. We hypothesized that compartmentalized generation of superoxide (O2‐) and nitric oxide (·NO) may be key events in the Ang II‐stimulated progression of ALI. Methods: Human alveolar ep…