Apocynin in the Treatment of Ischemic Stroke

Apocynin has been used as an efficient inhibitor of the NADPH oxidase complex in experimental studies. NADPH oxidase was originally identified immune cells as playing an important microbicidal role. In cerebral ischemia, inflammation is increasingly being recognized as contributing negatively to neurological outcome, with NADPH-oxidase as an important source of superoxide. Recently, several forms…