Expression and Modulation of an NADPH Oxidase in Mammalian A…

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Expression and Modulation of an NADPH Oxidase in Mammalian Astrocytes

Article 2005 EN Hybrid

Amyloid beta peptides generate oxidative stress in hippocampal astrocytes through a mechanism sensitive to inhibitors of the NADPH oxidase [diphenylene iodonium (DPI) and apocynin]. Seeking evidence for the expression and function of the enzyme in primary hippocampal astrocytes, we confirmed the expression of the subunits of the phagocyte NADPH oxidase by Western blot analysis and by immunofluores…

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6 authors
#AuthorInstitutionsORCID
1 Andrey Y. Abramov University College London (GB)
2 Jake Jacobson University College London (GB) —
3 Frans B. Wientjes University College London (GB) —
4 John Stephen Hothersall University College London (GB) —
5 Laura Canevari UCL Queen Square Institute of … (GB) —
6 Michael R. Duchen Corresponding University College London (GB)

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