Embryo secretome regulation of the endometrial epithelial tr…

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Embryo secretome regulation of the endometrial epithelial transcriptome: development of a model to test for embryo viability

Article 2026 EN Hybrid

The aim of this study was to develop an advanced in vitro model of human endometrium using single-cell-derived endometrial epithelial organoids, enabling the study of embryo secretome-endometrial crosstalk at the maternal-fetal interface. Single-cell-derived organoids generated from endometrial tissue of a parous 39-year-old woman recapitulated hormone-responsive decidualization, as demonstrated b…

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1 Zhixing Jin University of Oxford (GB) First Affiliated Hospital of S… (CN) —
2 Yifan Wang University of Oxford (GB) —
3 Abigail Freeman Blatchford University of Oxford (GB) —
4 Helena Rodriguez‐Caro University of Oxford (GB) Ludwig Cancer Research (CH) +1
5 Luyao Wang University of Oxford (GB)
6 Christian Malte Becker University of Oxford (GB)
7 PM Melo University of Oxford (GB) —
8 Tim J. Child University of Oxford (GB)
9 Rebecca Dragovic University of Oxford (GB)
10 Ingrid Granne University of Oxford (GB)
11 Jennifer H. Southcombe Corresponding University of Oxford (GB)

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