Targeted protein degradation via intramolecular bivalent glu…
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- DOI 10.1038/s41586-024-07089-6
- PMID https://pubmed.ncbi.nlm.nih.gov/38383787
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/10917667
- OpenAlex ID W4391994105
- Type Article
- Language EN
- Published 21 Feb 2024
- Volume 627 (8002)
- Pages 204–211
- Source Nature
- Publisher Nature Portfolio
- FWCI 28.62
- Countries 4
- Institutions 7
- Added 22 Feb 2024
- Updated 02 Nov 2026
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Targeted protein degradation via intramolecular bivalent glues
Article 2024 EN Hybrid
Abstract Targeted protein degradation is a pharmacological modality based on the induced proximity of an E3 ubiquitin ligase and a target protein to promote target ubiquitination and proteasomal degradation. This has been achieved either via bifunctional compounds (PROTACs) composed of two separate warheads that individually bind the target and E3 ligase, or via molecular glues that monovalently b…
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1 SDGsAuthors & Affiliations
21 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Oliver Hsia | University of Dundee (GB) | |
| 2 | Matthias Hinterndorfer | Austrian Academy of Sciences (AT) CeMM Research Center for Molec… (AT) | |
| 3 | Angus D. Cowan | University of Dundee (GB) | |
| 4 | Kentaro Iso | University of Dundee (GB) Eisai (Japan) (JP) | |
| 5 | Tasuku Ishida | University of Dundee (GB) Eisai (Japan) (JP) | |
| 6 | Ramasubramanian Sundaramoorthy | University of Dundee (GB) | |
| 7 | Mark A. Nakasone | University of Dundee (GB) | |
| 8 | Hana Imrichová | Austrian Academy of Sciences (AT) CeMM Research Center for Molec… (AT) | |
| 9 | Caroline Schätz | Austrian Academy of Sciences (AT) CeMM Research Center for Molec… (AT) | |
| 10 | Andrea Rukavina | Austrian Academy of Sciences (AT) CeMM Research Center for Molec… (AT) | |
| 11 | Koraljka Husnjak | Goethe University Frankfurt (DE) | |
| 12 | Martin Wegner | Goethe University Frankfurt (DE) | |
| 13 | Alejandro Correa-Sáez | University of Dundee (GB) | |
| 14 | Conner Craigon | University of Dundee (GB) | |
| 15 | Ryan Casement | University of Dundee (GB) | |
| 16 | Chiara Maniaci | University of Dundee (GB) MRC Protein Phosphorylation an… (GB) +1 | |
| 17 | Andrea Testa | University of Dundee (GB) | |
| 18 | Manuel Kaulich | Goethe University Frankfurt (DE) | |
| 19 | Ivan Đikić | Goethe University Frankfurt (DE) | |
| 20 | Georg E. Winter Corresponding | Austrian Academy of Sciences (AT) CeMM Research Center for Molec… (AT) | |
| 21 | Alessio Ciulli Corresponding | University of Dundee (GB) |
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