Ligandability of E3 Ligases for Targeted Protein Degradation…

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2021

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DOI 10.1021/acs.biochem.1c00464
PMID https://pubmed.ncbi.nlm.nih.gov/34473924
PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/8928483
OpenAlex ID W3197828497
Type Review
Language EN
Published 02 Sep 2021
Volume 62 (3)
Pages 588–600
Source Biochemistry
Publisher American Chemical Society
FWCI 2.02
Countries 1
Institutions 2
Added 13 Sep 2021
Updated 31 Oct 2026

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Ligandability of E3 Ligases for Targeted Protein Degradation Applications

Review 2021 EN Green

Targeted protein degradation (TPD) using proteolysis targeting chimeras (PROTACs) and molecular glue degraders has arisen as a powerful therapeutic modality for eliminating disease-causing proteins from cells. PROTACs and molecular glue degraders employ heterobifunctional or monovalent small molecules, respectively, to chemically induce the proximity of target proteins with E3 ubiquitin ligases to…

132

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3

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2.02

FWCI

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3 authors

#	Author	Institutions
1	Bridget P. Belcher	Innovative Genomics Institute (US) University of California, Berk… (US)
2	Carl C. Ward	Innovative Genomics Institute (US) University of California, Berk… (US)
3	Daniel K. Nomura Corresponding	Innovative Genomics Institute (US) University of California, Berk… (US)

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