A long-acting prolactin to combat lactation insufficiency
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Refs2023
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- DOI 10.1101/2023.12.15.571886
- PMID https://pubmed.ncbi.nlm.nih.gov/38168384
- OpenAlex ID W4389829322
- Type Preprint
- Language EN
- Published 15 Dec 2023
- Source bioRxiv (Cold Spring Harbor Laboratory)
- Publisher Cold Spring Harbor Laboratory
- Countries 1
- Institutions 6
- Added 10 Oct 2025
- Updated 22 Oct 2026
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A long-acting prolactin to combat lactation insufficiency
Preprint 2023 EN Green
. Here, we engineer a variant of the naturally-occurring driver of lactation, the hormone Prolactin, to increase its serum half-life and produce a viable drug candidate. Our engineered variant, Prolactin-eXtra Long-acting (Prolactin-XL), is comprised of endogenously active human prolactin fused to an engineered human IgG Fc domain designed to overcome the unique drug development challenges specifi…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
7 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Kasia M. Kready Corresponding | Harvard University (US) Center for Systems Biology (US) +1 | |
| 2 | Kailyn E. Doiron | Harvard University (US) Center for Systems Biology (US) +1 | |
| 3 | Katherine Redfield Chan | Brigham and Women's Hospital (US) | — |
| 4 | Jeffrey C. Way | Harvard University (US) Center for Systems Biology (US) +1 | |
| 5 | Quincey A. Justman | Harvard University (US) Center for Systems Biology (US) | |
| 6 | Camille Elise Powe | Broad Institute (US) Harvard University (US) +1 | |
| 7 | Pamela A. Silver Corresponding | Harvard University (US) Center for Systems Biology (US) +1 |
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