Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor wi…
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- DOI 10.3390/microorganisms11030717
- PMID https://pubmed.ncbi.nlm.nih.gov/36985290
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/10055926
- OpenAlex ID W4323844364
- Type Article
- Language EN
- Published 10 Mar 2023
- Volume 11 (3)
- Pages 717
- Source Microorganisms
- Publisher Multidisciplinary Digital Publishin…
- FWCI 1.03
- Countries 3
- Institutions 6
- Added 11 Mar 2023
- Updated 29 Oct 2026
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Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2
Article 2023 EN Gold
The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is partly under control by vaccination. However, highly potent and safe antiviral drugs for SARS-CoV-2 are still needed to avoid development of severe COVID-19. We report the discovery of a small molecule, Z-Tyr-Ala-CHN2, which was identified in a cell-based antiviral screen. The molecule exerts…
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22 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Jordi Doijen | Janssen (Belgium) (BE) | |
| 2 | Koen Temmerman | Janssen (Belgium) (BE) | — |
| 3 | Christel Van den Eynde | Janssen (Belgium) (BE) | — |
| 4 | Annick Diels | Janssen (Belgium) (BE) | — |
| 5 | Nick Van den Broeck | — | |
| 6 | Michiel Van Gool | — | |
| 7 | Inha Heo | Janssen (Belgium) (BE) | — |
| 8 | Steffen Jaensch | Janssen (Belgium) (BE) | |
| 9 | Marleen Zwaagstra | Utrecht University (NL) | |
| 10 | Mayra Diosa Toro | Utrecht University (NL) | |
| 11 | Winston Chiu | Rega Institute for Medical Res… (BE) KU Leuven (BE) | |
| 12 | Steven De Jonghe | Rega Institute for Medical Res… (BE) KU Leuven (BE) | |
| 13 | Pieter Leyssen | Rega Institute for Medical Res… (BE) KU Leuven (BE) | |
| 14 | Denisa Bojková | Goethe University Frankfurt (DE) University Hospital Frankfurt (DE) | |
| 15 | Sandra Ciesek | Goethe University Frankfurt (DE) University Hospital Frankfurt (DE) | |
| 16 | Jindrich Jr. Cinatl | Goethe University Frankfurt (DE) University Hospital Frankfurt (DE) | |
| 17 | Lore Verschueren | Janssen (Belgium) (BE) | — |
| 18 | Christophe Buyck | Janssen (Belgium) (BE) | |
| 19 | Frank J. M. van Kuppeveld | Utrecht University (NL) | |
| 20 | Johan H. Neyts | Rega Institute for Medical Res… (BE) KU Leuven (BE) | |
| 21 | Marnix Van Loock | Janssen (Belgium) (BE) | |
| 22 | Ellen Van Damme Corresponding | Janssen (Belgium) (BE) |
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