Potent Anti-SARS-CoV-2 Activity by the Natural Product Galli…
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- DOI 10.1021/acs.jmedchem.1c01494
- PMID https://pubmed.ncbi.nlm.nih.gov/34730959
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/8577376
- OpenAlex ID W3210259768
- Type Article
- Language EN
- Published 03 Nov 2021
- Volume 65 (4)
- Pages 2956–2970
- Source Journal of Medicinal Chemistry
- Publisher American Chemical Society
- FWCI 5.62
- Countries 3
- Institutions 10
- Added 08 Nov 2021
- Updated 31 Oct 2026
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Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L
Article 2021 EN Hybrid
High Resolution Image Download MS PowerPoint Slide Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2. The marine natural product gallinamide A and several synthetic analogues were identified as potent inhibitors of cathepsin L with IC 50 values in the picomolar range. Lead molecules possessed…
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21
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5.62
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21 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Anneliese S. Ashhurst | The University of Sydney (AU) | |
| 2 | Arthur H. Tang | The University of Sydney (AU) | |
| 3 | Pavla Fajtová | Czech Academy of Sciences (CZ) University of California San D… (US) +1 | |
| 4 | Michael C. Yoon | University of California San D… (US) | |
| 5 | Anupriya Aggarwal | UNSW Sydney (AU) Kirby Institute (AU) | |
| 6 | Max J. Bedding | The University of Sydney (AU) | |
| 7 | Alexander Stoye | The University of Sydney (AU) | — |
| 8 | Laura Beretta | University of California San D… (US) | — |
| 9 | Dustin Pwee | University of California San D… (US) | |
| 10 | Aleksandra K. Drelich | The University of Texas Medica… (US) | |
| 11 | Danielle Skinner | University of California San D… (US) | |
| 12 | Linfeng Li | Texas A&M University (US) | |
| 13 | Thomas D. Meek | Texas A&M University (US) | |
| 14 | James Hobson McKerrow | University of California San D… (US) | |
| 15 | VIVIAN Y. H. HOOK | University of California San D… (US) | |
| 16 | Chien-Te Kent Tseng | The University of Texas Medica… (US) | |
| 17 | Mark Larance | The University of Sydney (AU) | |
| 18 | Stuart Grant Turville | UNSW Sydney (AU) Kirby Institute (AU) | |
| 19 | William H. Gerwick Corresponding | Scripps Institution of Oceanog… (US) University of California San D… (US) | |
| 20 | Anthony John O’Donoghue Corresponding | University of California San D… (US) | |
| 21 | Richard J. Payne Corresponding | The University of Sydney (AU) Australian Research Council (AU) |
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