Splice-Variant Knock-Out of TGFβ Receptors Perturbates the P…

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DOI 10.3390/ijms222312647
PMID https://pubmed.ncbi.nlm.nih.gov/34884451
PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/8657817
OpenAlex ID W3216950345
Type Article
Language EN
Published 23 Nov 2021
Volume 22 (23)
Pages 12647
Source International Journal of Molecular Scien…
Publisher Multidisciplinary Digital Publishin…
FWCI 0.16
Countries 2
Institutions 4
Added 06 Dec 2021
Updated 28 Oct 2026

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Splice-Variant Knock-Out of TGFβ Receptors Perturbates the Proteome of Ovarian Carcinoma Cells

Article 2021 EN Gold

The aim of this study was to analyze the biological role of different transforming growth factor-β (TGFβ) receptor splice variants in ovarian carcinoma (OC). Specific receptor variant knockouts (KO) were prepared using the CRISPR/Cas9 genome editing system in two OC cell lines, TβRI variant 1 (TβRIv1) KO in ES-2 cells and TβRII variant 1 (TβRIIv1) KO in OVCAR-8 cells. Control and KO cells were com…

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5 authors

#	Author	Institutions	ORCID
1	Liora Jacobs Catane	Hebrew University of Jerusalem (IL)	—
2	Ofra Moshel	Hebrew University of Jerusalem (IL)	—
3	Yoav Smith	Hebrew University of Jerusalem (IL) Hadassah Medical Center (IL)
4	Ben Davidson	Oslo University Hospital (NO) University of Oslo (NO)
5	Reuven Reich Corresponding	Hebrew University of Jerusalem (IL)

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