Investigation of the roles of gastrin and histamine in gastric acid secretion using genetically engineered mouse models.

The primary objective of this research was to investigate the roles of gastrin and histamine in the regulation of acid secretion using genetically engineered mouse models. Previously, gastrin-deficient mice were shown to have an in vivo impairment in acid secretion. The first aim of this project was to test whether the reduction in acid secretion in gastrin-deficient mice was due to an intrinsic d…