Elevated MDM2 contributes to antitumor activity of p53-MDM2 …
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- OpenAlex ID W2562317541
- Type Article
- Language EN
- Published 01 Nov 2007
- Volume 6
- Source Molecular Cancer Therapeutics
- Publisher American Association for Cancer Res…
- Added 10 Oct 2025
- Updated 22 Sep 2026
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Elevated MDM2 contributes to antitumor activity of p53-MDM2 binding inhibitors
Article 2007 EN
C280 The p53 tumor suppressor is a powerful growth suppressive and pro-apoptotic molecule frequently inactivated in human cancer. MDM2, a negative p53 regulator, inhibits the transcriptional activity of p53 and facilitates its ubiquitin-dependent degradation. MDM2 is overproduced in many human tumors and effectively disables p53 function. Recently developed small-molecule MDM2 antagonists, the nut…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
5 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Mingxuan Xia | — | — |
| 2 | Dejan Knezevic | — | — |
| 3 | Christian Tovar | — | — |
| 4 | David C. Heimbrook | — | — |
| 5 | Lyubomir T. Vassilev | — |
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