Chemopreventive Agent 3,3′-Diindolylmethane Inhibits MDM2 in…

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  • DOI 10.3390/ijms21134642
  • PMID https://pubmed.ncbi.nlm.nih.gov/32629830
  • OpenAlex ID W3040365821
  • Type Article
  • Language EN
  • Published 30 Jun 2020
  • Volume 21 (13)
  • Pages 4642
  • Source International Journal of Molecular Scien…
  • Publisher Multidisciplinary Digital Publishin…
  • FWCI 1.28
  • Countries 1
  • Institutions 1
  • Added 10 Jul 2020
  • Updated 27 Oct 2026
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Chemopreventive Agent 3,3′-Diindolylmethane Inhibits MDM2 in Colorectal Cancer Cells

Article 2020 EN Gold

3,3'-Diindolylmethane (DIM) is a naturally derived chemopreventive compound. It comes from glucobrassicin, an indole glucosinolate enriched in cruciferous vegetables, and is formed in the acidic environment of the stomach after ingestion. Mouse double minute 2 homolog (MDM2) is an important, multi-functional oncogenic protein and it has been well recognized for its negative regulation of the tumor…

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1.28

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5 authors
#AuthorInstitutionsORCID
1 Xiang Gao University of Houston (US) —
2 Jingwen Liu University of Houston (US)
3 Kwang Bog Cho University of Houston (US)
4 Samanth R. Kedika University of Houston (US)
5 Bin Guo Corresponding University of Houston (US)
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