Single enantiomer drugs: should they be developed?

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  • PMID https://pubmed.ncbi.nlm.nih.gov/16989289
  • OpenAlex ID W2411637668
  • Type Article
  • Language EN
  • Published 01 Jan 2006
  • Volume 7 (1)
  • Pages 15–23
  • Source PubMed
  • Publisher National Institutes of Health
  • FWCI 0.15
  • Countries 1
  • Institutions 1
  • Added 10 Oct 2025
  • Updated 22 Sep 2026
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Single enantiomer drugs: should they be developed?

Article 2006 EN

Biological interactions are stereoselective; thus the interactions of drugs with corresponding biological targets must also be stereoselective. However, many drugs used today are racemic mixtures. For example, approximately 25% or 1 in 4 marketed drugs are mixtures of agents (racemates) rather than single chemical entities (enantiomers). One of these enantiomers can be inactive or even counterprod…

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UN Sustainable Development Goals
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3 authors
#AuthorInstitutionsORCID
1 Ahsan Yaqoob Khan University of Kansas (US) —
2 Sheldon Preskorn — —
3 Kandatege Wimalasena —

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