Covariation Is a Poor Measure of Molecular Coevolution
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- DOI 10.1093/molbev/msv109
- PMID https://pubmed.ncbi.nlm.nih.gov/25944916
- OpenAlex ID W2142431990
- Type Article
- Language EN
- Published 04 May 2015
- Volume 32 (9)
- Pages 2456–2468
- Source Molecular Biology and Evolution
- Publisher Oxford University Press
- FWCI 3.73
- Countries 2
- Institutions 2
- Added 10 Oct 2025
- Updated 14 Oct 2026
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Covariation Is a Poor Measure of Molecular Coevolution
Article 2015 EN Hybrid
Recent developments in the analysis of amino acid covariation are leading to breakthroughs in protein structure prediction, protein design, and prediction of the interactome. It is assumed that observed patterns of covariation are caused by molecular coevolution, where substitutions at one site affect the evolutionary forces acting at neighboring sites. Our theoretical and empirical results cast d…
53
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50
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3
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3.73
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Authors & Affiliations
3 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | David Talavera Corresponding | University of Manchester (GB) | |
| 2 | Simon C. Lovell | University of Manchester (GB) | |
| 3 | Simon Whelan | Uppsala University (SE) University of Manchester (GB) | — |
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