HLA-B-associated transcript 3 (Bat3)/Scythe is essential for…
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- DOI 10.1101/gad.1534107
- PMID https://pubmed.ncbi.nlm.nih.gov/17403783
- OpenAlex ID W2130076355
- Type Preprint
- Language EN
- Published 01 Apr 2007
- Volume 21 (7)
- Pages 848–861
- Source Genes & Development
- Publisher Cold Spring Harbor Laboratory Press
- Countries 2
- Institutions 5
- Added 10 Oct 2025
- Updated 16 Oct 2026
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HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
Preprint 2007 EN Diamond
In response to DNA damage, p53 undergoes post-translational modifications (including acetylation) that are critical for its transcriptional activity. However, the mechanism by which p53 acetylation is regulated is still unclear. Here, we describe an essential role for HLA-B-associated transcript 3 (Bat3)/Scythe in controlling the acetylation of p53 required for DNA damage responses. Depletion of B…
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6 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Toru Sasaki | University Health Network (CA) Campbell Family Institute for … (CA) | |
| 2 | Eugene C. Gan | Duke University (US) Duke Medical Center (US) | — |
| 3 | Andrew C. Wakeham | University Health Network (CA) Campbell Family Institute for … (CA) | — |
| 4 | Sally A. Kornbluth | Duke University (US) Duke Medical Center (US) | — |
| 5 | Tak W. Mak | University Health Network (CA) University of Toronto (CA) +1 | |
| 6 | Hitoshi Okada | University Health Network (CA) University of Toronto (CA) +1 |
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