Apparent hydroxyl radical production by peroxynitrite: impli…
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- DOI 10.1073/pnas.87.4.1620
- PMID https://pubmed.ncbi.nlm.nih.gov/2154753
- OpenAlex ID W2058137293
- Type Article
- Language EN
- Published 01 Feb 1990
- Volume 87 (4)
- Pages 1620–1624
- Source Proceedings of the National Academy of S…
- Publisher National Academy of Sciences
- FWCI 63.80
- Countries 1
- Institutions 1
- Added 10 Oct 2025
- Updated 23 Oct 2026
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Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
Article 1990 EN Green
Superoxide dismutase reduces injury in many disease processes, implicating superoxide anion radical (O2-.) as a toxic species in vivo. A critical target of superoxide may be nitric oxide (NO.) produced by endothelium, macrophages, neutrophils, and brain synaptosomes. Superoxide and NO. are known to rapidly react to form the stable peroxynitrite anion (ONOO-). We have shown that peroxynitrite has a…
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63.80
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1 SDGsAuthors & Affiliations
5 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Joseph S. Beckman | University of Alabama at Birmi… (US) | |
| 2 | T W Beckman | University of Alabama at Birmi… (US) | — |
| 3 | J Chen | University of Alabama at Birmi… (US) | — |
| 4 | Pamela A. Marshall | University of Alabama at Birmi… (US) | |
| 5 | Bruce Α. Freeman | University of Alabama at Birmi… (US) |
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