Curcumin-Induced Apoptosis in PC3 Prostate Carcinoma Cells I…
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- DOI 10.1080/01635580903441238
- PMID https://pubmed.ncbi.nlm.nih.gov/20358476
- OpenAlex ID W2026042453
- Type Article
- Language EN
- Published 01 Apr 2010
- Volume 62 (3)
- Pages 379–389
- Source Nutrition and Cancer
- Publisher Routledge
- FWCI 5.22
- Countries 1
- Institutions 1
- Added 24 Jun 2016
- Updated 31 Oct 2026
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Curcumin-Induced Apoptosis in PC3 Prostate Carcinoma Cells Is Caspase-Independent and Involves Cellular Ceramide Accumulation and Damage to Mitochondria
Article 2010 EN
Curcumin, the principal curcuminoid of tumeric, has potent anticancer activity. To determine the mechanism of curcumin-induced cytotoxicity in prostate cancer cells, we exposed PC3 prostate carcinoma cells to 25 to 100 microM curcumin for 24 to 72 h. Curcumin treatment of PC3 cells caused time- and dose-dependent induction of apoptosis and depletion of cellular reduced glutathione (GSH). Exogenous…
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8
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5.22
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1 SDGsAuthors & Affiliations
8 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Ashley L. Hilchie | Dalhousie University (CA) | — |
| 2 | Suzanne J. Furlong | Dalhousie University (CA) | — |
| 3 | Kimberly M. Sutton | Dalhousie University (CA) | — |
| 4 | Angela Mae Richardson | Dalhousie University (CA) | |
| 5 | Matthew Robichaud | Dalhousie University (CA) | — |
| 6 | Carman Anthony Giacomantonio | Dalhousie University (CA) | |
| 7 | Neale D. Ridgway | Dalhousie University (CA) | |
| 8 | David W. Hoskin | Dalhousie University (CA) |
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