The human oncoprotein MDM2 uses distinct strategies to inhib…
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- DOI 10.3892/ijo.18.3.449
- PMID https://pubmed.ncbi.nlm.nih.gov/11179471
- OpenAlex ID W2011292993
- Type Article
- Language EN
- Published 01 Mar 2001
- Volume 18 (3)
- Pages 449–59
- Source International Journal of Oncology
- Publisher Spandidos Publishing
- FWCI 0.54
- Countries 1
- Institutions 3
- Added 10 Oct 2025
- Updated 16 Oct 2026
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The human oncoprotein MDM2 uses distinct strategies to inhibit transcriptional activation mediated by the wild-type p53 and its tumor-derived mutants
Article 2001 EN
Human MDM2 (hMDM2) inhibits transcriptional activation mediated by wild-type p53 and its tumor-derived mutants. We present evidence to show that hMDM2 interacts with the tumor-derived mutants of p53 and inhibits transcriptional activation of the human c-myc promoter mediated by the tumor-derived mutants of p53 through two domains. These two domains of hMDM2 are able to function independent of each…
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1 SDGsAuthors & Affiliations
7 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Doris R. Brown | Virginia Commonwealth Universi… (US) VCU Massey Comprehensive Cance… (US) +1 | |
| 2 | Debabrita Deb | — | — |
| 3 | Rebecca A. Frum | — | — |
| 4 | Laura Hickes | — | — |
| 5 | Rubén M. Muñoz | — | — |
| 6 | Sumitra Deb | — | |
| 7 | Swati Palit Deb | — |
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