A New Class of Simplified Phorbol Ester Analogues: Synthesis…
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- DOI 10.1021/ol990809k
- PMID https://pubmed.ncbi.nlm.nih.gov/10825954
- OpenAlex ID W1965965826
- Type Article
- Language EN
- Published 04 Sep 1999
- Volume 1 (7)
- Pages 1009–1012
- Source Organic Letters
- Publisher American Chemical Society
- Countries 2
- Institutions 2
- Added 24 Jun 2016
- Updated 16 Oct 2026
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A New Class of Simplified Phorbol Ester Analogues: Synthesis and Binding to PKC and ηPKC-C1B (ηPKC-CRD2)
Article 1999 EN
[formula: see text] A unique class of simplified phorbol ester analogues is described for the first time. A highly efficient retro-annelation sequence was developed in order to remove the five-membered ring from the phorbol diterpene core, allowing access to BCD ring analogues of the phorbol esters. The binding of these analogues to protein kinase C (PKC) and the truncated peptide eta PKC-C1B (eta…
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5 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Paul A. Wender | Kyoto University (JP) Stanford University (US) | |
| 2 | Thorsten A. Kirschberg | Kyoto University (JP) Stanford University (US) | — |
| 3 | Peter D. Williams | Kyoto University (JP) Stanford University (US) | — |
| 4 | Harold M. M. Bastiaans | Kyoto University (JP) Stanford University (US) | — |
| 5 | Kazuhiro Irie | Kyoto University (JP) Stanford University (US) |
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