Genetic deletion of LDL receptor impairs mouse macrophage AB…
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- DOI 10.1096/fasebj.21.5.a16-c
- OpenAlex ID W149492663
- Type Article
- Language EN
- Published 01 Apr 2007
- Volume 21 (5)
- Source The FASEB Journal
- Publisher Wiley
- Countries 1
- Institutions 2
- Added 10 Oct 2025
- Updated 09 Oct 2026
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Genetic deletion of LDL receptor impairs mouse macrophage ABCA1 expression and cholesterol efflux: A new SREBP‐1 dependent mechanism
Article 2007 EN
LDLR mutations cause familial hypercholesterolemia and early atherosclerosis. Since ABCA1 facilitates free cholesterol efflux from peripheral tissues, we set out to investigate the effects of LDLR deletion (LDLR−/−) on macrophage ABCA1 expression and cholesterol efflux. LDLR−/− macrophages had reduced basal levels of ABCA1 and cholesterol efflux. High‐fat diet increased cholesterol in LDLR−/− macr…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
7 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Jihong Han | — | |
| 2 | Wei Song He | — | |
| 3 | Xiaoye Zhou | — | — |
| 4 | Zhiping Huang | — | |
| 5 | ANDREW C. NICHOLSON | — | |
| 6 | Antonio M. Gotto | Cornell University (US) Weill Cornell Medicine (US) | |
| 7 | David P. Hajjar | — | — |
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