Integrating Sequence and Structure for Annotating Proteins in the Twilight Zone: A Machine Learning Approach

Determining protein structure and function experimentally is both costly and time consuming. Transferring function-related protein annotations based on homology-based methods is relatively straightforward for proteins that have sequence identity of more than 40%. However, there are many proteins in the twilight zone where sequence similarity with any other protein is very weak, while being structu…