Beyond probiotics: targeting the microbiota-metabolite axis in radiation-induced diarrhea

Radiation-induced diarrhea remains a common complication of pelvic radiotherapy, with limited preventive strategies available. Although probiotics have been investigated as a potential supportive intervention, current evidence is heterogeneous and insufficient to support their routine use. Emerging data suggest that radiation-induced gut microbiota alterations and disruption of microbiota-derived…