Redox-activated induction of Warburg-type metabolism in the …
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- DOI 10.64898/2026.02.18.706512
- OpenAlex ID W7130597667
- Type Preprint
- Published 19 Feb 2026
- Source bioRxiv (Cold Spring Harbor Laboratory)
- Publisher Cold Spring Harbor Laboratory
- Countries 1
- Institutions 2
- Added 20 Feb 2026
- Updated 14 Oct 2026
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Redox-activated induction of Warburg-type metabolism in the adult heart
Preprint 2026 Green
Abstract Proliferating cells rewire glucose metabolism away from oxidative ATP production towards glycolysis and anabolic branch pathways (the Warburg effect). In contrast, the contractile function of terminally differentiated cardiomyocytes in the heart critically depends upon mitochondrial ATP generation. Adult cardiomyocytes are largely non-proliferative but undergo hypertrophy in response to i…
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1 SDGsAuthors & Affiliations
12 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Youwen Yang | King's College London (GB) British Heart Foundation (GB) | |
| 2 | Adam Nabeebaccus | King's College London (GB) British Heart Foundation (GB) | |
| 3 | Olga Mikhaylichenko | King's College London (GB) British Heart Foundation (GB) | |
| 4 | Christina Maria Reumiller | King's College London (GB) British Heart Foundation (GB) | |
| 5 | Domenico Cozzetto | King's College London (GB) British Heart Foundation (GB) | |
| 6 | Asjad Visnagri | King's College London (GB) British Heart Foundation (GB) | |
| 7 | Anna Zoccarato | King's College London (GB) British Heart Foundation (GB) | |
| 8 | Min Zhang | King's College London (GB) British Heart Foundation (GB) | |
| 9 | Alison C. Brewer | King's College London (GB) British Heart Foundation (GB) | |
| 10 | Anne Dragøy Hafstad | King's College London (GB) British Heart Foundation (GB) | |
| 11 | C X C Santos | King's College London (GB) British Heart Foundation (GB) | — |
| 12 | Ajay M. Shah Corresponding | King's College London (GB) British Heart Foundation (GB) |
Data: OpenAlex