Low-dose galactose rebalances HBP-mTORC1-SREBP-1c signaling …
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- DOI 10.1152/ajpgi.00379.2025
- PMID https://pubmed.ncbi.nlm.nih.gov/41528029
- OpenAlex ID W7123894905
- Type Article
- Language EN
- Published 13 Jan 2026
- Volume 330 (2)
- Pages G170–G188
- Source American Journal of Physiology-Gastroint…
- Publisher American Physiological Society
- Countries 1
- Institutions 1
- Added 14 Jan 2026
- Updated 16 Oct 2026
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Low-dose galactose rebalances HBP-mTORC1-SREBP-1c signaling to suppress hepatic lipogenesis and protect against early-stage alcohol-related liver disease
Article 2026 EN Hybrid
This study demonstrates that low-dose galactose, a dairy-derived monosaccharide, regulates hepatic de novo lipogenesis (DNL) by selectively inhibiting glucose-induced DNL activation. Mechanistically, low-dose galactose suppresses hexosamine biosynthetic pathway (HBP) flux, protein O-GlcNAcylation, and mTORC1 signaling, thereby inhibiting SREBP-1c activation in a Leloir pathway-dependent manner. No…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
7 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Yanhui Li Corresponding | University of Illinois Chicago (US) | |
| 2 | Rui Guo Corresponding | University of Illinois Chicago (US) | — |
| 3 | Yanyu Qian | University of Illinois Chicago (US) | — |
| 4 | Izabela Hawro | University of Illinois Chicago (US) | |
| 5 | José Córdoba‐Chacón | University of Illinois Chicago (US) | |
| 6 | Yuwei Jiang | University of Illinois Chicago (US) | |
| 7 | Zhenyuan Song | University of Illinois Chicago (US) |
Data: OpenAlex